VPS39

Across TCGA cell cohorts, VPS39 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,556 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS39-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Regulation of organelle assembly, and Macroautophagy. Each is linked with VPS39 in more than 18 cancer types. Because this analysis shows association rather than direction, both VPS39-to-partner and partner-to-VPS39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by VPS39-low versus VPS39-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS39→partner) and Y-score (partner→VPS39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+0.682	<.001	.009	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of organelle assembly →	+0.041	+0.911	<.001	<.001	3	19
STOMACH	Macroautophagy →	+0.090	+0.789	<.001	<.001	3	19
OESOPHAGUS	Regulation of myoblast fusion →	+0.148	+0.724	<.001	.004	3	19
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.154	+0.735	<.001	.007	3	19
STOMACH	Golgi vesicle transport →	+0.074	+0.697	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

Negative regulation of myoblast fusion by VPS39 expression — OESOPHAGUS

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