VPS37C

Across TCGA pan-cancer cohorts, VPS37C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS37C data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS37C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VPS37C expression acts as an unfavorable survival marker.

LUAD, KICH, and LIHC are the cancer types where VPS37C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.090	0.812	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
ESCA	OS	Median	II,III,IV	0.362	0.706	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS37C–LUAD (OS)

Open the LUAD breakdown →