VPS37C

Across TCGA pan-cancer cohorts, VPS37C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VPS37C data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VPS37C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VPS37C expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where VPS37C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.753	0.355	.001	26	view →
GBM	OS	Median	All	0.385	0.661	.011	7	view →
CCRCC	DFS	Median	All	0.978	0.891	.035	5	view →
UCEC	OS	Quartile	II,III,IV	0.523	1.000	.035	4	view →
LUAD	OS	Quartile	III,IV	0.719	0.272	.038	2	view →
LSCC	DFS	Quartile	II,III,IV	0.627	0.841	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VPS37C–PDAC (OS)

Open the PDAC breakdown →