VPS37C

Across TCGA patient cohorts, VPS37C mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS37C-associated genes across cancer lineages are A-Raf_pS299, ERK2, and IRS1. Each is linked with VPS37C in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37C-to-partner and partner-to-VPS37C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by VPS37C-low versus VPS37C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37C→partner) and Y-score (partner→VPS37C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.171	-3.169	.002	.019	3	1
UCEC	ERK2 →	+0.253	+3.169	.004	.019	3	1
UCEC	IRS1 →	-0.276	-3.000	.004	.036	3	1
UCEC	MSH6 →	-0.388	-2.999	.011	.035	3	1
UCEC	Akt_pT308 →	+0.587	+2.999	.045	.035	3	1
UCEC	p90 RSK →	+0.199	+2.598	.025	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by VPS37C expression — UCEC

Explore this box plot interactively →