VPS37C

Across TCGA cell cohorts, VPS37C mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS37C-associated genes across cancer lineages are MMP26, MAGEB4, and SPHKAP. Each is linked with VPS37C in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37C-to-partner and partner-to-VPS37C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by VPS37C-low versus VPS37C-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37C→partner) and Y-score (partner→VPS37C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	SPHKAP →	+0.006	+5.415	.007	.004	3	1
BLOOD_Leukemia	REG3A →	+0.114	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GALP →	+0.058	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MMP26 by VPS37C expression — BLOOD_Myeloma

Explore this box plot interactively →