VPS37B

Across TCGA pan-cancer cohorts, VPS37B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS37B data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS37B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VPS37B expression acts as an unfavorable survival marker.

HNSC, BLCA, and COAD are the cancer types where VPS37B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.169	0.710	.011	21	view →
BLCA	DFS	Median	IV	0.163	0.478	.048	3	view →
COAD	DFS	Median	All	0.212	0.696	.009	3	view →
SKCM	OS	Median	III,IV	0.216	0.801	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS37B–HNSC (OS)

Open the HNSC breakdown →