VPS37B

Across TCGA pan-cancer cohorts, VPS37B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS37B data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS37B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS37B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where VPS37B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.291	.001	44	view →
LUAD	DFS	Tertile	All	0.492	0.783	.008	16	view →
UCEC	DFS	Median	All	0.947	0.777	.008	10	view →
PDAC	OS	Tertile	III,IV	0.612	0.962	.022	4	view →
CCRCC	OS	Median	All	0.903	0.775	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS37B–HNSC (DFS)

Open the HNSC breakdown →