VPS37B

Across TCGA pan-cancer cohorts, VPS37B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VPS37B’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where VPS37B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VPS37B is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

PDAC, HNSC, and LUAD are the cancer types where VPS37B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS37B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.477	<.001	8	view →
HNSC	All	IV	−0.382	<.001	8	view →
LUAD	All	II,III,IV	+0.155	<.001	7	view →
CCRCC	All	All	−0.110	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

VPS37B–PDAC

Open the PDAC breakdown →