VPS37B

Across TCGA patient cohorts, VPS37B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS37B-associated genes across cancer lineages are CD20, EGFR_pY1068, and A-Raf_pS299. Each is linked with VPS37B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37B-to-partner and partner-to-VPS37B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD20 grouped by VPS37B-low versus VPS37B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37B→partner) and Y-score (partner→VPS37B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD20 →	-0.173	-2.459	.006	.020	3	2
UCEC	EGFR_pY1068 →	-0.344	-3.584	.004	.002	3	1
UCEC	A-Raf_pS299 →	-0.216	-3.169	<.001	.019	3	1
UCEC	JNK2 →	+0.317	+2.817	<.001	.036	3	1
UCEC	Ku80 →	+0.339	+3.179	.002	.010	3	1
UCEC	p62 Lck ligand →	+0.454	+2.179	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CD20 by VPS37B expression — UCEC

Explore this box plot interactively →