VPS37B

Across TCGA cell cohorts, VPS37B mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS37B-associated genes across cancer lineages are RIMS4, PHOX2B, and IFNG. Each is linked with VPS37B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37B-to-partner and partner-to-VPS37B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIMS4 grouped by VPS37B-low versus VPS37B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37B→partner) and Y-score (partner→VPS37B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIMS4 →	+0.211	+3.675	.002	.003	3	1
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	1
BLOOD_Leukemia	IFNG →	+0.128	+2.982	.001	.007	3	1
BLOOD_Leukemia	IL4 →	+1.532	+3.007	<.001	.007	3	1
BLOOD_Leukemia	HRG →	+0.261	+3.177	<.001	.004	3	1
BLOOD_Leukemia	CH25H →	+0.317	+3.557	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

RIMS4 by VPS37B expression — BLOOD_Leukemia

Explore this box plot interactively →