VPS37A

Across TCGA pan-cancer cohorts, VPS37A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS37A data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VPS37A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS37A expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where VPS37A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.346	.004	14	view →
LUAD	OS	Tertile	All	0.638	0.955	.009	10	view →
PDAC	DFS	Quartile	II,III,IV	0.550	0.320	.006	7	view →
HNSC	OS	Quartile	IV	0.883	0.605	.028	2	view →
CCRCC	OS	Median	All	0.774	0.892	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS37A–UCEC (DFS)

Open the UCEC breakdown →