VPS36

Across TCGA pan-cancer cohorts, VPS36 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS36 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS36 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS36 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BRCA, and UCEC are the cancer types where VPS36 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
BRCA	OS	Median	All	0.396	0.924	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.628	.018	18	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
SKCM	DFS	Median	All	0.199	0.730	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS36–HNSC (DFS)

Open the HNSC breakdown →