VPS36

Across TCGA pan-cancer cohorts, VPS36 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS36 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS36 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS36 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where VPS36 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.904	0.105	.017	27	view →
LUAD	DFS	Median	All	0.955	0.634	.005	15	view →
UCEC	OS	Quartile	All	1.000	0.884	.038	10	view →
PDAC	DFS	Quartile	All	0.538	0.367	.025	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS36–CCRCC (DFS)

Open the CCRCC breakdown →