VPS36

Across TCGA patient cohorts, VPS36 protein abundance is significantly associated with the RNA expression of many other genes, with 14,648 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible VPS36-associated genes across cancer lineages are VWA8, COG3, and CRYL1. Each is linked with VPS36 in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS36-to-partner and partner-to-VPS36 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS36 versus VWA8 in BRCA, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS36→partner) and Y-score (partner→VPS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VWA8 →	+0.660	+0.237	<.001	<.001	3	6
OV	COG3 →	+0.570	+0.306	.003	<.001	3	6
UCEC	CRYL1 →	+0.737	+0.179	<.001	<.001	3	6
OV	SPRYD7 →	+0.396	+0.199	.001	.001	3	6
COAD	NEK3 →	+0.584	+0.170	.007	.003	3	6
COAD	LNX2 →	+0.757	+0.232	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,648 associations by consensus.

VPS36 vs VWA8 — BRCA

Explore this scatter interactively →