VPS36

Across TCGA patient cohorts, VPS36 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS36-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with VPS36 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS36-to-partner and partner-to-VPS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by VPS36-low versus VPS36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS36→partner) and Y-score (partner→VPS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.518	+2.906	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.459	.006	.019	3	1
UCEC	eIF4E →	+0.182	+3.335	.042	.005	3	1
UCEC	ETS-1 →	+0.276	+3.169	.041	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-3.449	.033	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-2.000	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by VPS36 expression — UCEC

Explore this box plot interactively →