VPS36

Across TCGA cell cohorts, VPS36 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS36-associated genes across cancer lineages are NPHS2 and PRRG3. Each is linked with VPS36 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS36-to-partner and partner-to-VPS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by VPS36-low versus VPS36-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS36→partner) and Y-score (partner→VPS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPHS2 →	+0.073	+4.029	.009	.009	3	1
BLOOD_Leukemia	PRRG3 →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NPHS2 by VPS36 expression — LARGE_INTESTINE

Explore this box plot interactively →