VPS35L

Across TCGA pan-cancer cohorts, VPS35L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS35L data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS35L mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VPS35L expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where VPS35L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	1.000	0.727	.001	30	view →
CCRCC	OS	Quartile	III,IV	0.877	0.435	.002	25	view →
LUAD	OS	Quartile	III,IV	0.787	0.216	.008	4	view →
PDAC	DFS	Median	II,III,IV	0.691	0.851	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS35L–HNSC (OS)

Open the HNSC breakdown →