VPS35L

Across TCGA patient cohorts, VPS35L mutation is significantly associated with the RNA expression of many other genes, with 2,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS35L-associated genes across cancer lineages are RNU6-1169P, PCGF5, and DCLRE1A. Each is linked with VPS35L in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS35L-to-partner and partner-to-VPS35L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1169P grouped by VPS35L-low versus VPS35L-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS35L→partner) and Y-score (partner→VPS35L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-1169P →	+0.312	+4.421	<.001	.009	3	3
SKCM	PCGF5 →	+0.679	+3.813	.003	<.001	3	3
SKCM	DCLRE1A →	+0.626	+3.468	.007	.002	3	3
UCEC	XPNPEP1 →	+0.555	+3.000	<.001	<.001	3	3
UCEC	USP37 →	+0.487	+1.818	<.001	.002	3	3
UCEC	STAM →	+0.412	+2.016	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,766 associations by consensus.

RNU6-1169P by VPS35L expression — READ

Explore this box plot interactively →