VPS35L

Across TCGA cell cohorts, VPS35L mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS35L-associated genes across cancer lineages are OR1G1, SPATA31A5, and LGI1. Each is linked with VPS35L in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS35L-to-partner and partner-to-VPS35L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1G1 grouped by VPS35L-low versus VPS35L-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS35L→partner) and Y-score (partner→VPS35L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR1G1 →	+0.036	+6.247	<.001	<.001	3	1
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	HCRTR2 →	+0.010	+4.551	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR1G1 by VPS35L expression — BLOOD_Lymphoma

Explore this box plot interactively →