Across TCGA patient cohorts, VPS33B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS33B-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and G6PD. Each is linked with VPS33B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS33B-to-partner and partner-to-VPS33B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS33B→partner) and Y-score (partner→VPS33B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-2.295	.034	.033	3	1
UCEC	eIF4E →	+0.204	+3.183	.013	.009	3	1
UCEC	G6PD →	-0.305	-2.502	.016	.002	3	1
UCEC	MEK1 →	+0.496	+2.906	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.488	+3.817	<.001	<.001	3	1
UCEC	PI3K-p85 →	-0.207	-2.000	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

VPS33B survival (RNA) · tumor vs normal (RNA) · all VPS33B data types