Across TCGA pan-cancer cohorts, VPS33B-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated VPS33B-DT data layer compared with 1 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VPS33B-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VPS33B-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.
KIRC, KIRP, and UCS are the cancer types where VPS33B-DT RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.