VPS33A

Across TCGA pan-cancer cohorts, VPS33A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VPS33A data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher VPS33A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VPS33A expression acts as an unfavorable survival marker.

STAD, HNSC, and COAD are the cancer types where VPS33A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.184	0.730	.001	18	view →
HNSC	DFS	Median	All	0.365	0.713	.002	18	view →
COAD	DFS	Median	All	0.240	0.694	.001	15	view →
TGCT	DFS	Median	All	0.099	0.801	.011	6	view →
LUAD	OS	Median	All	0.397	0.702	.014	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	OS	Median	All	0.147	0.327	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VPS33A–STAD (OS)

Open the STAD breakdown →