VPS29

Across TCGA cell cohorts, VPS29 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,539 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible VPS29-associated GO terms across cancer lineages are Positive regulation of endosome organization, Centriole replication, and Chromosomal 5-methylcytosine DNA demethylation pathway. Each is linked with VPS29 in more than 8 cancer types. Because this analysis shows association rather than direction, both VPS29-to-partner and partner-to-VPS29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of endosome organization grouped by VPS29-low versus VPS29-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS29→partner) and Y-score (partner→VPS29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of endosome organization →	-0.179	-0.834	<.001	.003	3	9
BREAST	Centriole replication →	+0.075	+0.533	.003	.004	3	7
BREAST	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.136	+0.742	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.100	+0.796	.005	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.116	+0.970	<.001	.001	3	7
LIVER	Translation reinitiation →	+0.108	+0.533	.002	.003	1	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,539 associations by consensus.

Positive regulation of endosome organization by VPS29 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →