VPS26C

Across TCGA pan-cancer cohorts, VPS26C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VPS26C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VPS26C RNA is repressed in tumor relative to normal tissue. In most cancer types VPS26C is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where VPS26C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS26C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.619	<.001	10	view →
THCA	Male	III,IV	−0.484	<.001	10	view →
HNSC	Female	III,IV	+0.661	.003	7	view →
LIHC	All	All	+0.448	<.001	7	view →
KICH	All	All	−0.757	<.001	6	view →
LUAD	Female	All	−0.267	<.001	6	view →
KIRC	All	All	+0.248	<.001	6	view →
LUSC	Male	All	−0.367	<.001	4	view →
BRCA	All	II,III,IV	+0.139	.004	4	view →
CHOL	All	All	+0.790	.003	2	view →
KIRP	All	All	−0.301	.018	2	view →
READ	All	All	−0.354	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VPS26C–COAD

Open the COAD breakdown →