VPS26AP1

Across TCGA pan-cancer cohorts, VPS26AP1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated VPS26AP1 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher VPS26AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS26AP1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

ESCA, BLCA, and KIRP are the cancer types where VPS26AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.229	0.922	<.001	54	view →
BLCA	DFS	Median	III,IV	0.546	0.279	.006	30	view →
KIRP	DFS	Median	All	1.000	0.792	.002	22	view →
CESC	DFS	Quartile	All	0.894	0.782	.006	20	view →
BRCA	OS	Tertile	III,IV	0.968	0.876	.002	19	view →
DLBC	DFS	Tertile	II,III,IV	0.143	0.878	.008	18	view →
HNSC	DFS	Tertile	IV	0.772	0.459	.010	17	view →
UCEC	OS	Median	All	0.836	0.895	.016	14	view →
LUAD	DFS	Tertile	All	0.561	0.250	.014	10	view →
KICH	DFS	Median	IV	0.317	0.923	.038	9	view →
COAD	OS	Tertile	All	0.943	0.836	.015	5	view →
CHOL	DFS	Median	II,III,IV	0.708	0.220	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

VPS26AP1–ESCA (DFS)

Open the ESCA breakdown →