VPS26A

Across TCGA pan-cancer cohorts, VPS26A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS26A data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher VPS26A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VPS26A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, LUSC, and PRAD are the cancer types where VPS26A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.270	0.904	<.001	12	view →
LUSC	DFS	Median	All	0.185	0.758	.010	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.444	.037	6	view →
SKCM	OS	Median	All	0.117	0.343	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS26A–KIRP (OS)

Open the KIRP breakdown →