VPS26A

Across TCGA pan-cancer cohorts, VPS26A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS26A data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS26A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS26A expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where VPS26A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.344	0.837	.004	12	view →
PDAC	OS	Median	II,III,IV	0.619	0.385	.006	11	view →
CCRCC	DFS	Quartile	All	0.492	0.819	.034	2	view →
HNSC	OS	Quartile	III,IV	1.000	0.270	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS26A–LUAD (DFS)

Open the LUAD breakdown →