VPS26A

Across TCGA patient cohorts, VPS26A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS26A-associated genes across cancer lineages are 14-3-3_beta, ACC1, and Ku80. Each is linked with VPS26A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS26A-to-partner and partner-to-VPS26A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by VPS26A-low versus VPS26A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS26A→partner) and Y-score (partner→VPS26A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.108	-2.973	.017	.035	3	1
UCEC	ACC1 →	+0.443	+3.013	.006	.018	3	1
UCEC	Ku80 →	+0.331	+2.013	.001	.018	3	1
UCEC	MEK1 →	+0.445	+2.321	.006	.034	3	1
UCEC	Notch1 →	+0.234	+3.183	<.001	.009	3	1
UCEC	p62 Lck ligand →	+0.451	+2.710	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by VPS26A expression — UCEC

Explore this box plot interactively →