VPS18

Across TCGA pan-cancer cohorts, VPS18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS18 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS18 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VPS18 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, HNSC, and COAD are the cancer types where VPS18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	24	view →
HNSC	DFS	Tertile	III,IV	0.454	0.806	<.001	23	view →
COAD	DFS	Median	IV	0.565	1.000	.028	12	view →
UCEC	OS	Median	All	0.966	0.852	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS18–CCRCC (OS)

Open the CCRCC breakdown →