Across TCGA patient cohorts, VPS16 protein abundance is significantly associated with the RNA expression of many other genes, with 12,509 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VPS16-associated genes across cancer lineages are TMEM86A, CENPF, and VRK1. Each is linked with VPS16 in more than 6 cancer types. Because this analysis shows association rather than direction, both VPS16-to-partner and partner-to-VPS16 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS16→partner) and Y-score (partner→VPS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM86A →	+0.903	+0.108	<.001	.003	3	7
BRCA	CENPF →	-1.234	-0.171	<.001	<.001	3	6
HNSC	VRK1 →	-0.871	-0.115	<.001	<.001	3	5
BRCA	MCM4 →	-0.715	-0.155	.001	.002	2	6
LSCC	ASF1B →	-0.891	-0.156	<.001	<.001	3	5
BRCA	FOXM1 →	-1.356	-0.190	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,509 associations by consensus.

Exploration

VPS16 survival (RNA) · tumor vs normal (RNA) · all VPS16 data types