Across TCGA patient cohorts, VPS16 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS16-associated genes across cancer lineages are ATM, c-Met_pY1235, and JNK2. Each is linked with VPS16 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS16-to-partner and partner-to-VPS16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS16→partner) and Y-score (partner→VPS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.606	-2.000	<.001	.010	3	3
UCEC	c-Met_pY1235 →	+0.060	+1.584	.038	.036	3	3
UCEC	JNK2 →	+0.162	+2.331	.038	.019	3	2
UCEC	mTOR_pS2448 →	-0.178	-3.565	.002	.002	2	3
UCEC	VHL →	-0.764	-1.584	.004	.036	3	2
SKCM	Chk1 →	+0.349	+2.820	.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

VPS16 survival (RNA) · tumor vs normal (RNA) · all VPS16 data types