Across TCGA cell cohorts, VPS16 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS16-associated genes across cancer lineages are PRR27, MINAR2, and IDI2. Each is linked with VPS16 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS16-to-partner and partner-to-VPS16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS16→partner) and Y-score (partner→VPS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PRR27 →	+0.019	+3.906	<.001	.009	3	2
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	2
BLOOD_Myeloma	IDI2 →	+0.029	+3.906	.001	.009	3	1
BLOOD_Myeloma	C8B →	+0.059	+4.285	.007	.003	3	1
SOFT_TISSUE	IFNA8 →	+0.034	+4.930	<.001	.008	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

VPS16 survival (RNA) · tumor vs normal (RNA) · all VPS16 data types