VPS13D

Across TCGA pan-cancer cohorts, VPS13D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS13D data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS13D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS13D expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where VPS13D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.809	0.991	.001	18	view →
UCEC	DFS	Median	All	0.948	0.765	.004	10	view →
GBM	DFS	Median	All	0.246	0.483	.005	10	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →
HNSC	DFS	Tertile	IV	1.000	0.898	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS13D–LUAD (DFS)

Open the LUAD breakdown →