VPS13D

Across TCGA pan-cancer cohorts, VPS13D mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VPS13D’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where VPS13D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VPS13D is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where VPS13D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS13D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.356	<.001	11	view →
LSCC	Male	II,III,IV	−0.401	<.001	9	view →
LUAD	Male	All	−0.175	<.001	9	view →
HNSC	Male	All	−0.189	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

VPS13D–CCRCC

Open the CCRCC breakdown →