VPS13D

Across TCGA patient cohorts, VPS13D mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS13D-associated genes across cancer lineages are Cyclin-E2, Caveolin-1, and PDCD4. Each is linked with VPS13D in more than 4 cancer types. Because this analysis shows association rather than direction, both VPS13D-to-partner and partner-to-VPS13D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by VPS13D-low versus VPS13D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13D→partner) and Y-score (partner→VPS13D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.195	+2.484	.024	.010	3	5
BLCA	Caveolin-1 →	-0.742	-2.000	<.001	.007	3	4
UCEC	PDCD4 →	-0.414	-1.807	<.001	<.001	3	4
UCEC	ASNS →	+0.310	+1.378	<.001	.005	3	4
STAD	C-Raf →	+0.151	+3.000	.013	.033	3	3
STAD	c-Kit →	-0.295	-3.000	.014	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Cyclin-E2 by VPS13D expression — COAD

Explore this box plot interactively →