VPS13D

Across TCGA cell cohorts, VPS13D mutation is significantly associated with the RNA expression of many other genes, with 1,767 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS13D-associated genes across cancer lineages are MFAP3L, SLC25A11, and MFN2. Each is linked with VPS13D in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS13D-to-partner and partner-to-VPS13D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFAP3L grouped by VPS13D-low versus VPS13D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS13D→partner) and Y-score (partner→VPS13D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFAP3L →	+0.896	+2.459	<.001	.003	3	4
LARGE_INTESTINE	SLC25A11 →	+0.520	+1.721	.001	.003	3	3
LARGE_INTESTINE	MFN2 →	+0.565	+2.000	.002	.009	3	3
LARGE_INTESTINE	CTBS →	+0.836	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	MPDU1 →	+0.513	+1.807	.001	.003	3	3
LARGE_INTESTINE	ILKAP →	+0.400	+3.321	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,767 associations by consensus.

MFAP3L by VPS13D expression — LARGE_INTESTINE

Explore this box plot interactively →