VPS13C

Across TCGA pan-cancer cohorts, VPS13C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of VPS13C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VPS13C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VPS13C is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where VPS13C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS13C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−0.350	<.001	11	view →
CCRCC	Male	III,IV	−0.256	<.001	11	view →
LSCC	Male	II,III,IV	−0.531	<.001	8	view →
OV	All	All	−0.243	.028	2	view →
LUAD	All	All	−0.055	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

VPS13C–COAD

Open the COAD breakdown →