VPS13B

Across TCGA pan-cancer cohorts, VPS13B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VPS13B data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS13B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VPS13B expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where VPS13B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.823	0.289	<.001	28	view →
UCEC	DFS	Tertile	II,III,IV	0.917	0.336	.003	24	view →
LSCC	DFS	Median	II,III,IV	0.631	0.912	.003	21	view →
HNSC	DFS	Tertile	III,IV	0.892	1.000	.014	5	view →
CCRCC	OS	Tertile	All	1.000	0.531	.015	5	view →
GBM	OS	Quartile	All	0.618	0.311	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VPS13B–LUAD (OS)

Open the LUAD breakdown →