VNN3

Across TCGA pan-cancer cohorts, VNN3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VNN3 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VNN3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VNN3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where VNN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.955	0.657	.002	10	view →
HNSC	DFS	Quartile	III,IV	0.256	0.851	.038	4	view →
LUAD	OS	Median	II,III,IV	0.443	1.000	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VNN3–LSCC (OS)

Open the LSCC breakdown →