Across TCGA pan-cancer cohorts, VN1R88P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of VN1R88P’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where VN1R88P RNA is repressed in tumor relative to normal tissue. In most cancer types VN1R88P is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA and LIHC are the cancer types where VN1R88P tumor–normal differential expression is most reproducible.