Across TCGA pan-cancer cohorts, VN1R34P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VN1R34P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where VN1R34P RNA is repressed in tumor relative to normal tissue. In most cancer types VN1R34P is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.
THCA, HNSC, and COAD are the cancer types where VN1R34P tumor–normal differential expression is most reproducible.