VN1R1

Across TCGA patient cohorts, VN1R1 mutation is significantly associated with the RNA expression of many other genes, with 515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VN1R1-associated genes across cancer lineages are NPIPA2, RNA5SP391, and RNU6-618P. Each is linked with VN1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VN1R1-to-partner and partner-to-VN1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPIPA2 grouped by VN1R1-low versus VN1R1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VN1R1→partner) and Y-score (partner→VN1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NPIPA2 →	+0.029	+7.640	<.001	.009	3	2
LUAD	RNA5SP391 →	+0.248	+7.930	<.001	.008	3	2
UCEC	RNU6-618P →	+0.242	+2.510	.008	.001	3	2
UCEC	RNA5SP198 →	+0.426	+2.921	<.001	.002	3	2
UCEC	RNA5SP408 →	+0.311	+2.486	<.001	.008	3	2
HNSC	OR13C9 →	+0.052	+5.468	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 515 associations by consensus.

NPIPA2 by VN1R1 expression — BLCA

Explore this box plot interactively →