VN1R1

Across TCGA patient cohorts, VN1R1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VN1R1-associated genes across cancer lineages are S6_pS235_S236, S6_pS240_S244, and Tuberin_pT1462. Each is linked with VN1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VN1R1-to-partner and partner-to-VN1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by VN1R1-low versus VN1R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VN1R1→partner) and Y-score (partner→VN1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS235_S236 →	+0.454	+2.000	.020	.032	3	1
UCEC	S6_pS240_S244 →	+0.505	+2.700	.005	.006	3	1
UCEC	Tuberin_pT1462 →	+0.293	+3.331	.004	.005	3	1
UCEC	ATM →	-0.538	-2.000	.008	.032	3	1
UCEC	Caspase-8 →	-0.237	-3.143	.036	.018	3	1
UCEC	Akt_pT308 →	+0.592	+2.000	.037	.032	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

S6_pS235_S236 by VN1R1 expression — UCEC

Explore this box plot interactively →