VMO1

Across TCGA patient cohorts, VMO1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VMO1-associated genes across cancer lineages are FOXO3a_pS318_S321, IRS1, and MAPK_pT202_Y204. Each is linked with VMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VMO1-to-partner and partner-to-VMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by VMO1-low versus VMO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VMO1→partner) and Y-score (partner→VMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.157	-3.312	.009	.010	3	1
UCEC	IRS1 →	-0.258	-3.000	.010	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.495	-3.156	.029	.018	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.459	.043	.020	3	1
UCEC	P-Cadherin →	-0.191	-2.999	.006	.035	3	1
UCEC	Shc_pY317 →	-0.282	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FOXO3a_pS318_S321 by VMO1 expression — UCEC

Explore this box plot interactively →