Across TCGA patient cohorts, VMAC mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VMAC-associated genes across cancer lineages are RNU4-82P, KRTAP20-3, and TRAJ54. Each is linked with VMAC in more than 1 cancer types. Because this analysis shows association rather than direction, both VMAC-to-partner and partner-to-VMAC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VMAC→partner) and Y-score (partner→VMAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-82P →	+0.606	+3.829	.001	.005	3	1
UCEC	KRTAP20-3 →	+0.182	+6.060	<.001	<.001	3	1
UCEC	TRAJ54 →	+0.691	+3.599	<.001	.007	3	1
UCEC	TRAJ52 →	+1.034	+3.434	<.001	.006	3	1
UCEC	TRAJ20 →	+1.211	+3.914	<.001	.002	3	1
UCEC	IGHD3-16 →	+1.859	+4.417	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

VMAC survival (RNA) · tumor vs normal (RNA) · all VMAC data types