VLDLR

Across TCGA pan-cancer cohorts, VLDLR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VLDLR data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VLDLR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VLDLR expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where VLDLR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.659	1.000	<.001	61	view →
PDAC	DFS	Quartile	All	0.627	0.908	<.001	52	view →
GBM	OS	Tertile	All	0.451	0.645	.011	7	view →
LUAD	DFS	Quartile	II,III,IV	0.389	0.748	.027	2	view →
LSCC	DFS	Quartile	All	0.534	1.000	.049	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VLDLR–CCRCC (OS)

Open the CCRCC breakdown →