VLDLR

Across TCGA patient cohorts, VLDLR protein abundance is significantly associated with the RNA expression of many other genes, with 9,288 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible VLDLR-associated genes across cancer lineages are VLDLR-AS1, RASGRP2, and SNX31. Each is linked with VLDLR in more than 7 cancer types. Because this analysis shows association rather than direction, both VLDLR-to-partner and partner-to-VLDLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VLDLR versus VLDLR-AS1 in LSCC, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VLDLR→partner) and Y-score (partner→VLDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VLDLR-AS1 →	+0.840	+0.745	<.001	<.001	3	8
CCRCC	RASGRP2 →	-0.706	-0.458	<.001	<.001	3	4
HNSC	SNX31 →	-1.154	-0.582	<.001	<.001	3	4
HNSC	ANXA2 →	+1.044	+0.471	<.001	.007	3	4
CCRCC	SULF2 →	+0.686	+0.452	.008	.003	3	4
HNSC	PKM →	+0.612	+0.538	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,288 associations by consensus.

VLDLR vs VLDLR-AS1 — LSCC

Explore this scatter interactively →