VLDLR

Across TCGA patient cohorts, VLDLR mutation is significantly associated with the RNA expression of many other genes, with 2,495 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VLDLR-associated genes across cancer lineages are SLC7A11, C18orf25, and PELO. Each is linked with VLDLR in more than 1 cancer types. Because this analysis shows association rather than direction, both VLDLR-to-partner and partner-to-VLDLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A11 grouped by VLDLR-low versus VLDLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VLDLR→partner) and Y-score (partner→VLDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC7A11 →	+0.825	+2.513	<.001	<.001	3	2
UCEC	C18orf25 →	+0.400	+1.788	.001	.001	3	2
UCEC	PELO →	+0.497	+2.389	<.001	<.001	3	2
UCEC	ABHD3 →	+0.602	+2.069	<.001	<.001	3	2
UCEC	CHAF1B →	+0.616	+3.338	<.001	<.001	3	2
UCEC	GFI1 →	+0.436	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,495 associations by consensus.

SLC7A11 by VLDLR expression — UCEC

Explore this box plot interactively →