VLDLR

Across TCGA cell cohorts, VLDLR mutation is significantly associated with the RNA expression of many other genes, with 215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VLDLR-associated genes across cancer lineages are OR10G4, NEIL2, and CENPVL3. Each is linked with VLDLR in more than 1 cancer types. Because this analysis shows association rather than direction, both VLDLR-to-partner and partner-to-VLDLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G4 grouped by VLDLR-low versus VLDLR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VLDLR→partner) and Y-score (partner→VLDLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10G4 →	+0.014	+3.185	<.001	.006	3	2
LARGE_INTESTINE	NEIL2 →	+0.954	+3.364	<.001	.002	3	2
LARGE_INTESTINE	CENPVL3 →	+0.141	+2.183	<.001	.007	3	2
LUNG_NSCLC_LUAD	SSMEM1 →	+0.051	+3.906	<.001	.002	3	2
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

OR10G4 by VLDLR expression — BLOOD_Leukemia

Explore this box plot interactively →