Across TCGA pan-cancer cohorts, VKORC1L1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VKORC1L1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VKORC1L1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VKORC1L1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where VKORC1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.875	0.347	.013	19	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	17	view →
LSCC	DFS	Median	All	0.577	0.893	.018	7	view →
PDAC	DFS	Median	All	0.254	0.437	.020	4	view →
HNSC	OS	Quartile	II,III,IV	0.784	0.542	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: VKORC1L1 tumor-vs-normal RNA expression · all VKORC1L1 data types